Protease inhibitor (Pi) locus, fertility and twinning
نویسندگان
چکیده
منابع مشابه
Protease inhibitor (Pi) phenotypes in chromosome aberrations.
Many enzymes and several enzyme inhibitors are found in multiple molecular forms in different human populations. Some of them constitute important polymorphic systems useful for populations genetics, forensic medicine, and chromosome mapping. However, little is known about the distribution ofthese genetic markers in patients with chrosome aberrations and their parents. The purpose ofthe present...
متن کاملJE-2147: a dipeptide protease inhibitor (PI) that potently inhibits multi-PI-resistant HIV-1.
We designed, synthesized, and identified JE-2147, an allophenylnorstatine-containing dipeptide HIV protease inhibitor (PI), which is potent against a wide spectrum of HIV-1, HIV-2, simian immunodeficiency virus, and various clinical HIV-1 strains in vitro. Drug-resistant clinical HIV-1 strains, isolated from seven patients who had failed 9-11 different anti-HIV therapeutics after 32-83 months, ...
متن کاملMale fertility defects in mice lacking the serine protease inhibitor protease nexin-1.
Understanding infertility and sterility requires knowledge of the molecular mechanisms underlying sexual reproduction. We have found that male mice deficient for the gene encoding the protease inhibitor protease nexin-1 (PN-1) show a marked impairment in fertility from the onset of sexual maturity. Absence of PN-1 results in altered semen protein composition, which leads to inadequate semen coa...
متن کاملFamilial twinning and fertility in Dutch mothers of twins.
We studied twinning and fertility indices in mothers with spontaneous monozygotic (MZ) and dizygotic (DZ) twins and in mothers who conceived their twins after the use of assisted reproduction techniques (ART). Participants in this study consisted of 8,222 and 5,505 women with spontaneous DZ and MZ offspring and 4,164 and 250 women with ART DZ and MZ twin pairs, respectively. Women were compared...
متن کاملPatient Characteristics and Treatment Outcome Associated with Protease Inhibitor (PI) use in the Asia-Pacific Region.
OBJECTIVES: Regimens containing protease inhibitors (PI) are less commonly used in developing countries due to high cost and less availability. We evaluated characteristics of patients initiating PI-based therapy according to previous antiretroviral (ARV) exposure; factors associated with initiating a PI-containing regimen using newer versus older PIs, and proportion of patients with detectable...
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ژورنال
عنوان ژورنال: Human Genetics
سال: 1992
ISSN: 0340-6717,1432-1203
DOI: 10.1007/bf00220552